Spleen Tyrosine Kinase (Syk), a Novel Target of Curcumin, Is Required for B Lymphoma Growth

Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth.

Curcumin (diferuloylmethane), a component of dietary spice turmeric (Curcuma longa), has been shown in recent studies to have therapeutic potential in the treatment of cancer, diabetes, arthritis, and osteoporosis. We investigated the ability of curcumin to modulate the growth of B lymphomas. Curcumin inhibited the growth of both murine and human B lymphoma in vitro and murine B lymphoma in viv...

Spleen Tyrosine Kinase: A Novel Target in Autoimmunity

Spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis.

BACKGROUND Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. The objective of this phase 2 study was to evaluate the efficacy and safety of R788, an oral inhibitor of Syk, in patients with active rheumatoid arthritis despite methotrexate therapy. METHODS We enrolled 457 patients who had active rheumatoid arthritis despite long-term methotrexate therapy in a 6-month, ...

An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis

From the Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston (M.E.W.); Division of Rheumatology, University of California at San Diego, San Diego (A.K.); Division of Rheumatology, Stanford University, Palo Alto, CA (M.G.); and Rigel, South San Francisco, CA (T.K.M., E.B.G., D.B.M.). Address reprint requests to Dr. Weinblatt at the D...

Syk Tyrosine Kinase Is Required for the Positive Selection of Immature B Cells into the Recirculating B Cell Pool

The tyrosine kinase Syk has been implicated as a key signal transducer from the B cell antigen receptor (BCR). We show here that mutation of the Syk gene completely blocks the maturation of immature B cells into recirculating cells and stops their entry into B cell follicles. Furthermore, using radiation chimeras we demonstrate that this developmental block is due to the absence of Syk in the B...